What is the most important information I should know about Gabapentin? Patients, has a relatively mild side-effect profile, and passes through the body unmetabolized. Gabapentin is sometimes effectiveness for patients who have failed to respond to antidepressants or mood stabilizers. Gabapentin helps keep the nerve activity in the brain. Gabapentin works by stabilizing electrical activity in the brain. You can be pain free and experience a full range of motion instantly! Multiple sclerosis.