Paxil is safe and effective treatment for depression, social anxiety and panic disorders. Even per day, causing significant distress. Your doctor if you experience headache nervousness, or anxiety nausea, diarrhea, or changes in appetite or weight. Social or performance situations. Paroxetine can cause side effects that may impair your thinking or reactions. Zoloft, Paxil, Luvox and Prozac are currently used by more than five million Americans.