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Before using this medication, tell your doctor or pharmacist your medical history, especially of blood flow problem in the brain. The enzyme that makes prostaglandins, resulting in lower concentrations of prostaglandins. Celecoxib is used to treat arthritis, pain, menstrual cramps, and colonic polyps. Celecoxib differs from other NSAIDs in that it causes less inflammation and ulceration of the stomach and intestine and does not interfere with the clotting of blood. Ask your doctor, nurse, or pharmacist any questions you may have about this medicine. Before taking Celecoxib, tell your doctor or pharmacist if you are allergic to it or to sulfa drugs. Celebrex works by blocking the action of a substance in the body called cyclo-oxygenase.