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Keflex can be used as first-line therapy for MRSA infections and is the most prescribed oral cephalosporin medicine. Patients and a thorough medical history is recommended prior to prescribing this medication. Medications with known interactions with Keflex include blood thinners, probenecid, and Metformin. Keflex may not be well tolerated by all patients and a thorough medical history is recommended prior to prescribing this medication. Side effects of Cephalexin are diarrhea, nausea, abdominal pain, vomiting, headaches, dizziness, skin rash and fever. Keflex is a cephalosporin antibiotic used to treat bacterial infections of the skin, urinary tract, respiratory tract, bones, and joints.