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Medications with known interactions with Keflex include blood thinners, probenecid, and Metformin. Keflex is a semi-synthetic cephalosporin antibiotic for oral administration. Medications with known interactions with Keflex include blood thinners, probenecid, and Metformin. Take Keflex at even intervals around the clock as prescribed by your doctor. This is likely to result in an overdose. Take Keflex at even intervals around the clock as prescribed by your doctor. Cephalexin may be given on an empty stomach or with food to prevent stomach upset.