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Minor side effects are appetite loss, drowsiness, diarrhea, metallic taste, headaches, stomach upset and vomiting. Metronidazole is usually taken two or three times a day for ten days or longer. Minor side effects are appetite loss, drowsiness, diarrhea, metallic taste, headaches, stomach upset and vomiting. Flagyl, generically known as Metronidazole, is prescribed for the treatment of serious infections caused by susceptible anaerobic bacteria. Metronidazole is a valuable antibiotic and is generally well tolerated with appropriate use. It is important to maintain a constant level of Flagyl in the blood.