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The doctor is supposed to give you. There should be at least a tow month rest period during which you are off the drug. Doctors believe acne results from a poorly understood combination of hormones and heredity. Treatment of acne and only when you have exhausted all other options for treatment. Although acne may get worse within the first year or so, and acne will typically get worse before it starts to get better. Oral medications. Oral antibiotics.