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Propranolol should be administered with caution since it may block bronchodilation produced by endogenous and exogenous catecholamine stimulation of beta-adrenergic receptors. Propranolol is used to prevent migraine, although it is not fully understood how Propranolol works in this area. Propranolol may reduce the oxygen requirement of the heart and so decreases its demand for oxygen. Several reports in the published literature describe cases in which Propranolol was used as a suicide agent. Care should be taken if adrenaline is given with Propranolol, laboratory determinations should be made at regular intervals. Propranolol reduces the workload of the heart and so decreases its demand for oxygen.