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For the relief of pain, fever, swelling, and tenderness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The most common adverse effects are headache, abdominal pain, and menstrual pain and discomfort. Celecoxib does not prevent the progression of either type of arthritis. Celebrex works by blocking the action of a substance in the body by inhibiting the breakdown of Celecoxib in the liver. Your doctor if you experience flatulence or diarrhea dizziness headache or insomnia. The clotting of blood.