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There are no restrictions on food, beverages, or activities while taking Nexium, unless otherwise directed by your doctor. Esomeprazole works best if taken on an empty stomach at least one hour before meals, swallowed whole and shouldn't be crushed or chewed. There are no restrictions on food, beverages, or activities while taking Nexium, unless otherwise directed by your doctor. If taken on an empty stomach at least one hour before a meal. Nexium decreases the amount of acid backing up into the esophagus and causing reflux symptoms.
